GENETIC-CONTROL OF POLYKETIDE BIOSYNTHESIS IN THE GENUS STREPTOMYCES

被引：0
|
作者：
HUTCHINSON, CR [1 ]
DECKER, H [1 ]
MADDURI, K [1 ]
OTTEN, SL [1 ]
TANG, L [1 ]
机构：
[1] UNIV WISCONSIN,DEPT BACTERIOL,MADISON,WI 53706
来源：
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY | 1993年 / 64卷 / 02期
关键词：
ACTINORHODIN; ANTIBIOTICS; DAUNORUBICIN; ERYTHROMYCIN; TETRACENOMYCIN; TYLOSIN;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The genetic control of polyketide metabolite biosynthesis in Streptomyces sp. producing actinorhodin, daunorubicin, erythromycin, spiramycin, tetracenomycin and tylosin is reviewed. Several examples of positively-acting transcriptional regulators of polyketide metabolism are known, including some two-component sensor kinase-response regulator systems. Translational and posttranslational control mechanisms are only briefly mentioned since very little is known about either of these processes. Examples of how enzyme levels and substrate supply affect polyketide metabolism also are discussed.
引用
收藏
页码：165 / 176
页数：12
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