REACTIONS OF COPPER-COMPLEXES WITH OXYGEN RADICALS GENERATED BY HUMAN NEUTROPHILS

被引：2
|
作者：
HASELOFF, RF
GRUNER, S
WISCHNEWSKY, GG
机构：
[1] HUMBOLDT UNIV,BEREICH MED CHARITE,SCH MED,O-1040 BERLIN,GERMANY
[2] BERLIN CHEM AG,BERLIN,GERMANY
来源：
JOURNAL OF BIOLUMINESCENCE AND CHEMILUMINESCENCE | 1992年 / 7卷 / 03期
关键词：
COPPER COMPLEXES; SUPEROXIDE; RADICAL; CHEMILUMINESCENCE; LUMINOL;
D O I：
10.1002/bio.1170070303
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The intensity of the chemiluminescence of unstimulated human neutrophils in the presence of luminol was used to investigate the effects of low-molecular-weight copper complexes at the cellular level. In different models (superoxide dismutase mimetic activity, inhibition of haematoporphyrin derivative/light-induced lysis of cells), the biological activity of the complexes exceeded the activity of the ligands alone.
引用
收藏
页码：171 / 175
页数：5
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