TRANSLOCATION T(11-22)(Q23-Q11) IN AN ADULT WITH ACUTE MONOBLASTIC LEUKEMIA

被引：0
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作者：
KOBAYASHI, H
MIYACHI, H
OGAWA, T
JIMBO, M
机构：
来源：
JAPANESE JOURNAL OF MEDICINE | 1990年 / 29卷 / 05期
关键词：
CHIMERIC BCR-ABL MESSENGER RNA; DELETION-7Q; TRISOMY-8; MYELOMONOCYTIC PROGENITOR CELLS; LINEAGE SWITCH;
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暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 66-year-old woman with acute monoblastic leukemia with t(11;22)(q23;q11), which was subsequently transformed into myeloblastic leukemia is reported. Such karyotype abnormality has not been reported in acute monoblastic leukemia. Cytogenetic analysis revealed 47,XX, +8, t(11;22)(q23;q11) in 19 out of 20 metaphases and 46, XX, del(7)(q22-q36), t(11;22)(q23;q11) in the remaining metaphase. Variant Ph1 was ruled out due to the absence of chimeric bcr-abl mRNAs. In remission cytogenetic findings showed normal karyotype. After 4 months, the patient relapsed with 20% myeloblasts replacing monoblasts in bone marrow. Cytogenetic analysis revealed 46, XX, del(7)(q22-q36), t(11;22)(q23;q11) in all metaphases. A possible explanation for this lineage switch may be the involvement of myelomonocytic progenitor cells.
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页码：527 / 532
页数：6
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