It has recently become accepted that the activated immune system communicates to brain via release of pro-inflammatory cytokines. This review examines the possibility that pro-inflammatory cytokines (interleukins and/or tumor necrosis factor) mediate a variety of commonly studied hyperalgesic states. We will first briefly review basic immune responses and inflammation. We will then develop the concept of illness responses and provide evidence for their existence and for the dramatic changes in neural functioning that they cause. Lastly, we will examine the potential roles that both pro-inflammatory cytokines and the neural circuits that they activate may play in the hyperalgesic states produced by irritants, inflammatory agents, and nerve damage. The possibility is raised that apparently diverse hyperalgesic states may converge in the central nervous system and activate similar or identical neural circuitry.
机构:
Department of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, ChandigarhDepartment of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Chandigarh
Singh S.
Ramani P.
论文数: 0|引用数: 0|
h-index: 0|
机构:
Department of Oral Pathology, Saveetha Dental College and Hospital, SIMATS, Tamil Nadu, ChennaiDepartment of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Chandigarh
Ramani P.
Jayakumar N.D.
论文数: 0|引用数: 0|
h-index: 0|
机构:
Department of Periodontics, Saveetha Dental College and Hospital, SIMATS, Tamil Nadu, ChennaiDepartment of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Chandigarh
Jayakumar N.D.
Pannu S.J.
论文数: 0|引用数: 0|
h-index: 0|
机构:
Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, ChandigarhDepartment of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Chandigarh
Pannu S.J.
Sharma R.K.
论文数: 0|引用数: 0|
h-index: 0|
机构:
Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Chandigarh
Department of Biochemistry, Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, ChandigarhDepartment of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Chandigarh
Sharma R.K.
Gill S.S.
论文数: 0|引用数: 0|
h-index: 0|
机构:
Government Medical College & Hospital, ChandigarhDepartment of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Chandigarh