SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF [E]-5-(2-ACYLVINYL)URACILS

被引：28
|
作者：
KUNDU, NG [1 ]
DASGUPTA, SK [1 ]
CHAUDHURI, LN [1 ]
MAHANTY, JS [1 ]
SPEARS, CP [1 ]
SHAHINIAN, AH [1 ]
机构：
[1] UNIV SO CALIF,CTR COMPREHENS CANC,CANC RES LAB,LOS ANGELES,CA 90033
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 06期
关键词：
E]-5-(2-ACYLVINYL)URACILS; ANTICANCER AGENTS; THYMIDYLATE SYNTHASE INHIBITORS;
D O I：
10.1016/0223-5234(93)90015-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of a number of 5-substituted uracils, eg [E]-5-(2-acylvinyl)uracils 8a-8g is described. These compounds were found to have cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells. These compounds were also found to inhibit thymidylate synthase.
引用
收藏
页码：473 / 479
页数：7
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