COMPARISON OF THE MODE OF ACTION OF RAS P21 WITH THOSE OF PROTEIN KINASE-A AND KINASE-C IN THE STIMULATION OF GENE-EXPRESSION IN NIH-3T3 CELLS

被引：5

作者：

OKU, N ^{[1
]}

KAIBUCHI, K ^{[1
]}

FUKUMOTO, Y ^{[1
]}

HORI, Y ^{[1
]}

FUJIOKA, H ^{[1
]}

TAKAI, Y ^{[1
]}

机构：

[1] KOBE UNIV,SCH MED,DEPT BIOCHEM,KOBE 650,JAPAN

来源：

FEBS LETTERS | 1990年 / 269卷 / 01期

关键词：

Enhancer/promoter; NIH/3T3; cell; Protein kinases A and C; ras p21;

D O I：

10.1016/0014-5793(90)81141-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To compare the mode of action of ras p21 with those of protein kinases A and C in the regulation of gene expression in NIH/3T3 cells, we investigated the transcriptional activity of various enhancer/promoters and enhancer motifs in the cells transfected with the c-Ha-rasval12 complementary DNA (cDNA). The results indicate that the c-Ha-rasval12 protein stimulates the enhancer/promoters of the c-fos gene, the metallothionein IIA gene, the simian virus 40 (SV40) virus genome and the Rous sarcoma (RS) virus genome, and the serum-response element and the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element in a manner independent of protein kinases A and C in NIH/3T3 cells. © 1990.

引用

页码：148 / 152

页数：5

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