COMPARISON OF THE MODE OF ACTION OF RAS P21 WITH THOSE OF PROTEIN KINASE-A AND KINASE-C IN THE STIMULATION OF GENE-EXPRESSION IN NIH-3T3 CELLS

被引：5
|
作者：
OKU, N [1 ]
KAIBUCHI, K [1 ]
FUKUMOTO, Y [1 ]
HORI, Y [1 ]
FUJIOKA, H [1 ]
TAKAI, Y [1 ]
机构：
[1] KOBE UNIV,SCH MED,DEPT BIOCHEM,KOBE 650,JAPAN
来源：
FEBS LETTERS | 1990年 / 269卷 / 01期
关键词：
Enhancer/promoter; NIH/3T3; cell; Protein kinases A and C; ras p21;
D O I：
10.1016/0014-5793(90)81141-A
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To compare the mode of action of ras p21 with those of protein kinases A and C in the regulation of gene expression in NIH/3T3 cells, we investigated the transcriptional activity of various enhancer/promoters and enhancer motifs in the cells transfected with the c-Ha-rasval12 complementary DNA (cDNA). The results indicate that the c-Ha-rasval12 protein stimulates the enhancer/promoters of the c-fos gene, the metallothionein IIA gene, the simian virus 40 (SV40) virus genome and the Rous sarcoma (RS) virus genome, and the serum-response element and the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element in a manner independent of protein kinases A and C in NIH/3T3 cells. © 1990.
引用
收藏
页码：148 / 152
页数：5
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