BIOAVAILABILITY OF TOBACCO-SPECIFIC N-NITROSAMINES TO THE SNUFF DIPPER

被引：16
|
作者：
PROKOPCZYK, B
WU, M
COX, JE
HOFFMANN, D
机构：
[1] Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla
来源：
CARCINOGENESIS | 1992年 / 13卷 / 05期
关键词：
D O I：
10.1093/carcin/13.5.863
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Use of supercritical carbon dioxide extraction in the analysis of smokeless tobacco for tobacco-specific N-nitrosamines revealed the presence of higher levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) than had been determined with conventional methods. Whether human saliva may be similarly capable of releasing apparently bound NNK during chewing or snuff dipping was tested by incubating smokeless tobacco with enzymatically active saliva and with heat-treated saliva respectively. Enzymatically active human saliva was found to liberate up to twice the amount of the highly carcinogenic NNK than did heat-treated saliva. This is of major consequence for the cancer risk assessment of snuff dippers and tobacco chewers.
引用
收藏
页码：863 / 866
页数：4
相关论文
共 50 条
  • [41] Tobacco-specific nitrosamines
    Hecht, SS
    Borukhova, A
    Carmella, SG
    [J]. NICOTINE SAFETY AND TOXICITY, 1998, : 67 - 75
  • [42] Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry
    Stepanov, Irina
    Knezevich, Aleksandar
    Zhang, Liqin
    Watson, Clifford H.
    Hatsukami, Dorothy K.
    Hecht, Stephen S.
    [J]. TOBACCO CONTROL, 2012, 21 (01) : 44 - 48
  • [43] Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines
    Stanfill, Stephen B.
    Connolly, Gregory N.
    Zhang, Liqin
    Jia, Lily T.
    Henningfield, Jack E.
    Richter, Patricia
    Lawler, Tameka S.
    Ayo-Yusuf, Olalekan A.
    Ashley, David L.
    Watson, Clifford H.
    [J]. TOBACCO CONTROL, 2011, 20 (03) : 1 - 10
  • [44] TOBACCO-SPECIFIC N-NITROSAMINES [TSNA] IN GREEN MATURE AND PROCESSED TOBACCO-LEAVES FROM INDIA
    BHIDE, SV
    NAIR, J
    MARU, GB
    NAIR, UJ
    RAO, BVK
    CHAKRABORTY, MK
    BRUNNEMANN, KD
    [J]. BEITRAGE ZUR TABAKFORSCHUNG INTERNATIONAL, 1987, 14 (01): : 29 - 32
  • [45] TOBACCO SPECIFIC N-NITROSAMINES - OCCURRENCE AND BIOASSAYS
    HOFFMANN, D
    ADAMS, JD
    BRUNNEMANN, KD
    RIVENSON, A
    HECHT, SS
    [J]. IARC PUBLICATIONS, 1982, (41): : 309 - 318
  • [46] UPTAKE AND METABOLISM OF CARCINOGENIC LEVELS OF TOBACCO-SPECIFIC NITROSAMINES BY SUDANESE SNUFF DIPPERS
    MURPHY, SE
    CARMELLA, SG
    IDRIS, AM
    HOFFMANN, D
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 1994, 3 (05) : 423 - 428
  • [47] CARCINOGENICITY OF TOBACCO-SPECIFIC N-NITROSAMINES (TSNA) - THE ROLE OF THE VASCULAR NETWORK IN THE SELECTION OF TARGET ORGANS
    RIVENSON, A
    HECHT, SS
    HOFFMANN, D
    [J]. CRITICAL REVIEWS IN TOXICOLOGY, 1991, 21 (04) : 255 - 264
  • [48] METABOLISM AND TISSUE DISTRIBUTION OF TOBACCO-SPECIFIC N-NITROSAMINES IN THE MARMOSET MONKEY (CALLITHRIX-JACCHUS)
    CASTONGUAY, A
    TJALVE, H
    TRUSHIN, N
    DARGY, R
    SPERBER, G
    [J]. CARCINOGENESIS, 1985, 6 (11) : 1543 - 1550
  • [49] ANTIMUTAGENIC EFFECTS OF BETEL LEAF EXTRACT AGAINST THE MUTAGENICITY OF 2 TOBACCO-SPECIFIC N-NITROSAMINES
    PADMA, PR
    AMONKAR, AJ
    BHIDE, SV
    [J]. MUTAGENESIS, 1989, 4 (02) : 154 - 156
  • [50] Tobacco-specific N-nitrosamines NNN and NNK levels in cigarette brands between 2000 and 2014
    Gunduz, I.
    Kondylis, A.
    Jaccard, G.
    Renaud, J. -M.
    Hofer, R.
    Ruffieux, L.
    Gadani, F.
    [J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2016, 76 : 113 - 120
12345