INVOLVEMENT OF HISTIDINE-RESIDUES IN CATALYTIC ACTIVITY OF XANTHINE DEHYDROGENASE FROM HEN LIVER

被引：1
|
作者：
ZAKRZEWSKA, B
KAMINSKI, ZW
机构：
[1] Department of Comparative Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-532
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 03期
关键词：
D O I：
10.1016/0020-711X(92)90043-Z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. Modification of histidine residue(s) of xanthine dehydrogenase from hen liver by DEP and photooxidation results in loss of the ability to transfer electrons from xanthine to NAD+ and also from NADH to 2,6-dichlorophenolindophenol (DCIP). 2. The kinetics of inactivation suggest that carbethoxylation of more than one histidyl residue in the enzyme may be responsible for the inactivation.
引用
收藏
页码：487 / 491
页数：5
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