A NEW AND FACILE SYNTHETIC ROUTE TO N5-FORMYL TETRAHYDROPTEROYLPOLY-L-GLUTAMATES

被引：2
|
作者：
FITZHUGH, AL
CHMURNY, GN
KLOSE, JR
机构：
[1] DynCorp NCI-Frederick Cancer Research, Development Center, Medicinal Chemistry Section, Frederick, MD 21702-1201, P.O. Box B
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 03期
关键词：
D O I：
10.1016/S0960-894X(01)80789-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A simple, wholly chemical method has been found for preparing N5-formyl tetrahydropteroylpoly-L-glutamates. The method involves: (1) forming an alpha-monoester of N5-formyl tetrahydropteroylmono-L-glutamic acid, (2) coupling its "free" gamma-carboxyl end with an L-glutamate polyester (3) deprotection to give the desired product.
引用
收藏
页码：155 / 158
页数：4
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