ELIMINATION OF ANTIPYRINE AND ITS METABOLITES IN INTERFERON-TREATED HEPATITIS-C

被引：4
|
作者：
SIECK, JO
ELYAZIGI, A
ALI, H
DOSSING, M
SAOUR, J
RAINES, DA
ERNST, P
机构：
[1] BISPEBJERG HOSP,DEPT MED P,DK-2400 COPENHAGEN,DENMARK
[2] KING FAISAL SPECIALIST HOSP & RES CTR,DEPT MED,RIYADH 11211,SAUDI ARABIA
[3] KING FAISAL SPECIALIST HOSP & RES CTR,DEPT BIOL & MED RES,RIYADH 11211,SAUDI ARABIA
[4] KING FAISAL SPECIALIST HOSP & RES CTR,DEPT ONCOL,RIYADH 11211,SAUDI ARABIA
来源：
HUMAN & EXPERIMENTAL TOXICOLOGY | 1994年 / 13卷 / 09期
关键词：
D O I：
10.1177/096032719401300902
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
1 To study the effect of interferon on hepatic drug metabolism in chronic hepatitis C, we examined nine patients before and at the end of 6 months of interferon treatment. 2 Routine liver function was determined together with the salivary clearance of antipyrine and the 48 h urinary excretion of the main metabolites of antipyrine: 4-hydroxyantipyrine 3-hydroxymethylantipyrine and norantipyrine before and after 6 months of interferon treatment. 3 Liver pathology, routine liver function, and antipyrine metabolism remained unchanged after patients were treated for 6 months with interferon for a histologically advanced but clinically compensated chronic hepatitis C. ,
引用
收藏
页码：598 / 601
页数：4
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