Human pluripotent stem cells;
Human embryonic stem cells;
Stem cell act;
Developmental toxicity;
Germ cell differentiation;
D O I:
10.1007/s10304-012-0477-7
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Human embryonic stem cells and, more generally, human pluripotent stem cells have attracted much interest for nearly 15 years. The German Stem Cell Act that came into effect on 1 July 2002 strictly regulates research in human embryonic stem cells. This article introduces currently available human pluripotent stem cell types, gives an overview on potential options to use these cells beyond research and summarizes present research activities involving human pluripotent stem cells in Germany. In particular, German research projects with the aim of establishing novel cell models for the detection of human-specific developmental toxicity in vitro are discussed and efforts to develop human germ cells from human pluripotent stem cells are presented.
机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
Damdimopoulou, Pauliina
Rodin, Sergey
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机构:
Karolinska Inst, Dept Biochem & Biophys, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
Rodin, Sergey
Stenfelt, Sonya
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机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
Stenfelt, Sonya
Antonsson, Liselotte
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机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
Antonsson, Liselotte
Tryggvason, Karl
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机构:
Karolinska Inst, Dept Biochem & Biophys, Stockholm, Sweden
Duke NUS Grad Med Sch, Cardiovasc & Metab Disorders Program, Singapore, SingaporeKarolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
Tryggvason, Karl
Hovatta, Outi
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机构:
Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, SwedenKarolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden