Life-threatening haematemesis associated with clozapine: a case report and literature review

被引：2
|
作者：
Adebayo, Kazeem Olaide [1 ]
Ibrahim, Nurudeen [1 ]
Mosanya, Temilola [1 ]
Eegunranti, Benjamin [1 ]
Suleiman, Babatunde [1 ]
Ayankunle, Akeem [2 ]
机构：
[1] Ladoke Akintola Univ, Teaching Hosp, Dept Psychiat, Osogbo, Nigeria
[2] LAUTECH Univ, Dept Pharmacol & Therapeut, Osogbo, Nigeria
来源：
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY | 2013年 / 3卷 / 05期
关键词：
clozapine; haematemesis; schizophrenia;
D O I：
10.1177/2045125313481026
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Clozapine is regarded as a second-line and in some cases last-line antipsychotic known for its common life-threatening side effects, such as agranulocytosis, constipation and cardiomyopathies, but rarely haematemesis. We report a case of severe haemetemesis in a chronic schizophrenic patient managed with clozapine. The patient was a 46-year-old male being managed for chronic schizophrenia with treatment resistance who developed sudden severe haematemesis following commencement of clozapine for 6 weeks. The patient had 1.1 l of blood transfusion. The relevant literature is reviewed. Clozapine can be associated with a life-threatening haematemesis. Psychiatrists and other medical specialists need to be alert to the fatality of clozapine-induced haematemesis in the treatment of psychiatric disorders.
引用
收藏
页码：275 / 277
页数：3
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