MAGNESIUM-DEPENDENT CALCIUM EFFLUX IN MAMMALIAN HEART-MUSCLE

被引：6
|
作者：
VIERLING, W [1 ]
STAMPFL, A [1 ]
机构：
[1] GSF MUNICH,UMWELT & GESUNDHEIT FORSCHUNGSZENTRUM,INST TOXICOL,NEUHERBERG,GERMANY
来源：
CELL CALCIUM | 1994年 / 15卷 / 02期
关键词：
D O I：
10.1016/0143-4160(94)90056-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Extra and intracellular magnesium is involved in the control of myocardial calcium movements. Here we report on an increase in cytosolic calcium concentration in resting Ventricular myocytes due to the withdrawal of extracellular magnesium under the condition of a blocked sodium-dependent calcium elimination. Evidence for an activation of cellular calcium efflux by extracellular magnesium showed experiments in perfused hearts. It is concluded that extracellular magnesium can modulate the intracellular free calcium concentration of the myocardial cell by its influence on calcium elimination.
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页码：175 / 182
页数：8
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