MOLECULAR MODELING OF THE ANTAGONIST BINDING-SITE ON THE ADENOSINE-A1-RECEPTOR

被引：0

作者：

IJZERMAN, AP ^{[1
]}

VANGALEN, PJM ^{[1
]}

VANVLIJMEN, HWT ^{[1
]}

SOUDIJN, W ^{[1
]}

NISSEN, P ^{[1
]}

VANWIJNGAARDEN, I ^{[1
]}

机构：

[1] DUPHAR BV,1380 AA WEESP,NETHERLANDS

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 05期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With the aid of molecular modelling both adenosine and adenosine A1 receptor antagonists belonging to various chemical classes were compared. A model for the antagonist binding site was developed. As a consequence H-1-imidazo[4,5-c]-quinolin-4-amines were synthesized, constituting a novel class of potent non-xanthine adenosine receptor antagonists.

引用

页码：1039 / 1047

页数：9

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