MOLECULAR MODELING OF THE ANTAGONIST BINDING-SITE ON THE ADENOSINE-A1-RECEPTOR

被引：0
|
作者：
IJZERMAN, AP [1 ]
VANGALEN, PJM [1 ]
VANVLIJMEN, HWT [1 ]
SOUDIJN, W [1 ]
NISSEN, P [1 ]
VANWIJNGAARDEN, I [1 ]
机构：
[1] DUPHAR BV,1380 AA WEESP,NETHERLANDS
来源：
NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 05期
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
With the aid of molecular modelling both adenosine and adenosine A1 receptor antagonists belonging to various chemical classes were compared. A model for the antagonist binding site was developed. As a consequence H-1-imidazo[4,5-c]-quinolin-4-amines were synthesized, constituting a novel class of potent non-xanthine adenosine receptor antagonists.
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页码：1039 / 1047
页数：9
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