Distinct clinical characteristics of familial and solitary patients with bipolar disorder

被引:2
|
作者
Atagun, Murat Ilhan [1 ]
Cevahirli, Esra Sena [1 ]
Kara, Tugba [1 ]
Tabakci, Sencer [1 ]
Balaban, Ozlem Devrim [1 ]
Yesilbas, Dilek [1 ]
机构
[1] Bakirkoy Res & Training Hosp Psychiat Neurol & Ne, Istanbul, Turkey
关键词
Familial; non-familial; bipolar disorder;
D O I
10.5455/jmood.20110816022359
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Major mental disorders including bipolar disorder aggregate in families. There are also non-familial, solitary cases and familial and non-familial cases may differ. Most of the studies regarding familiality in bipolar disorder targeted similar and dissimilar characteristics of the disease within families. There is a lack of studies targeting between subject differences in patients from different families. The aim of this study is to assess and compare clinical characteristics of type I bipolar patients with and without a family history of bipolar disorders. Method: This study was conducted on outpatients of Rasit Tahsin Mood Disorders Centre of Bakirky Research and Training Hospital. The medical records of 112 participants (69 female, 43 male, mean age: 41.54 +/- 11.19, range: 22-75, 64 of which had family history and 48 without family history) with type I Bipolar Disorder were collected. Missing information was obtained by phone interviews from both patients and first degree relatives. Information of the patients without a family history of any psychiatric disorder was checked with a senior family member. Results: Postpartum episode rates, comorbid psychiatric disorders, number of subjects ever had past mixed episodes, and nicotine dependency rates were found to be significantly higher in patients with family history. No significant difference was detected between groups in terms of age, gender, education, age at disease onset, number of episodes, and number of hospitalizations. Conclusions: Comorbidity, postpartum episodes, lifetime mixed episodes, and smoking were found to be higher in patients with family history and thus associated with bipolarity. Postpartum episodes and comorbidities can be expected to be more prevalent in patients with family history. However clinical characteristics should be further investigated in larger samples.
引用
收藏
页码:110 / 117
页数:8
相关论文
共 50 条
  • [21] The effect of residual symptoms on clinical characteristics and functioning of patients with bipolar disorder in remission
    Canbazoglu, Mustafa
    Akkaya, Cengiz
    Cangur, Sengul
    Kirli, Selcuk
    ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY, 2013, 14 (03): : 228 - 236
  • [22] Discrete cognitive subgroups in euthymic patients with bipolar disorder: Demographic and clinical characteristics
    Tsapekos, Dimosthenis
    Strawbridge, Rebecca
    Mantingh, Tim
    Cella, Matteo
    Wykes, Til
    Young, Allan H.
    BIPOLAR DISORDERS, 2020, 22 : 104 - 105
  • [23] Comparison of Sociodemographic and Clinical Characteristics of Patients with Bipolar Disorder with and without Guardianship Decision
    Kulacaoglu, Filiz
    Izci, Filiz
    Aslan, Metin
    Kolsuz, Hilal
    Calli, Sumeyye
    Fidan, Yagmur Sever
    NAMIK KEMAL MEDICAL JOURNAL, 2023, 11 (03): : 186 - 192
  • [24] Clinical characteristics and current treatment of patients with bipolar disorder in a Russian psychiatric hospital
    Semenova, OE
    Ivanov, VB
    Tochilov, VA
    Isacsson, G
    EUROPEAN PSYCHIATRY, 2004, 19 : 203S - 203S
  • [25] Memory functioning in familial bipolar I disorder patients and their relatives
    Quraishi, Seema
    Walshe, Muriel
    McDonald, Colm
    Schulze, Katja
    Kravariti, Eugenia
    Bramon, Elvira
    Morris, Robin G.
    Murray, Robin M.
    Toulopoulou, Timothea
    BIPOLAR DISORDERS, 2009, 11 (02) : 209 - 214
  • [26] Clinical characteristics of "bipolar disorder, not otherwise specified" in relation to the bipolar spectrum
    Bader, CD
    Dunner, DL
    BIOLOGICAL PSYCHIATRY, 2005, 57 (08) : 92S - 92S
  • [27] Seasonality and its distinct clinical correlates in bipolar ii disorder: a comparison study with bipolar I disorder and major depressive disorder
    Kim, J.
    Ha, T. H.
    Park, Y. S.
    Chang, J. S.
    Kim, J.
    Hong, K. S.
    Ha, K. S.
    BIPOLAR DISORDERS, 2014, 16 : 78 - 78
  • [28] Comparison of clinical features in familial early and adult onset bipolar disorder
    Kent, L
    Heron, J
    Gordon-Smith, K
    Craddock, N
    AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 114 (07): : 765 - 766
  • [29] Clinical Outcome of Adolescents and Young Adults at Familial Risk for Bipolar Disorder
    Pandina, Gahan
    Drevets, Wayne
    Rassnick, Stephanie
    Bhavna, Solanki
    Canuso, Carla
    Fristad, Mary
    Correll, Christoph
    Nurnberger, John
    Singh, Manpreet
    Weisler, Richard
    McInnis, Melvin
    Atkinson, Sarah
    Stedman, Mary
    Goes, Fernando S.
    Thurman, Louise
    Strakowski, Stephen
    Greer, Tracy
    Nierenberg, Andrew
    Salvadore, Giacomo
    DelBello, Melissa
    NEUROPSYCHOPHARMACOLOGY, 2021, 46 (SUPPL 1) : 225 - 226
  • [30] Clinical and biological predictors of bipolar disorder in youth at high familial risk
    Mitchell, P. B.
    Frankland, A.
    Roberts, G.
    Holmes-Preston, E.
    Perich, T.
    Levy, F.
    Lenroot, R.
    Hadzi-Pavlovic, D.
    Breakspear, M.
    BIPOLAR DISORDERS, 2018, 20 : 40 - 40