TYROSINE KINASE INHIBITORS REGULATE SEROTONIN UPTAKE IN PLATELETS

被引：27

作者：

HELMESTE, DM ^{[1
]}

TANG, SW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,IRVINE MED CTR,DEPT PSYCHIAT,ORANGE,CA 92668

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 280卷 / 02期

关键词：

GENISTEIN; ERBSTATIN ANALOG; CA2+;

D O I：

10.1016/0014-2999(95)00323-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Uptake of tritiated serotonin into human platelets was found to be rapidly inhibited by the tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate. Binding studies indicated that uptake inhibition did not correlate with direct binding of these inhibitors to the transporter. Chelation of mobilizable intracellular Ca2+ did not inhibit the effects of genistein on uptake. These results suggest a more direct, non-Ca2+ mediated effect of tyrosine kinase inhibitors on uptake.

引用

页码：R5 / R7

页数：3

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