Recurrence of herpes simplex encephalitis associated with temozolomide chemoradiation for malignant glioma: a case report and review of the literature

被引：7

作者：

Christman, Mitalee P. ^{[1
]}

Turbett, Sarah E. ^{[2
]}

Sengupta, Soma ^{[3
]}

Bakhadirov, Khamidulla U. ^{[4
]}

Williamson, Craig A. ^{[5
]}

Nayak, Lakshmi ^{[6
]}

Milligan, Tracey ^{[4
]}

Katz, Joel T. ^{[7
]}

机构：

[1] Harvard Med Sch, Boston, MA 02115 USA

[2] Massachusetts Gen Hosp, Harvard Med Sch, Div Infect Dis, Boston, MA 02114 USA

[3] Beth Israel Deaconess Med Ctr, Harvard Med Sch, Dept Neurol, Boston, MA 02215 USA

[4] Brigham & Womens Hosp, Harvard Med Sch, Dept Neurol, Boston, MA 02115 USA

[5] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA

[6] Dana Farber Canc Inst, Ctr Neuro Oncol, Harvard Med Sch, Boston, MA 02215 USA

[7] Brigham & Womens Hosp, Harvard Med Sch, Div Infect Dis, 75 Francis St, Boston, MA 02115 USA

来源：

OXFORD MEDICAL CASE REPORTS | 2014年 / 01期

关键词：

D O I：

10.1093/omcr/omu001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although herpes simplex encephalitis is not classically considered an opportunistic infection, reactivation of herpes simplex is being seen increasingly in patients with cancer or immunosuppression. The authors present a patient with malignant glioma and HSV-1 encephalitis whose PCR-proven encephalitis recurred after temozolomide (TMZ) chemoradiation despite acyclovir therapy, and summarize details of four other cases of HSV-1 encephalitis associated with TMZ. The similarity among these cases raises the likely need for longer treatment courses and/or oral suppressive therapy in patients at risk for herpes simplex infections who are receiving TMZ.

引用

页码：1 / 4

页数：4

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