Alzheimer's disease: amyloid-based pathogenesis and potential therapies

被引：25

作者：

Zhou, Yixiu ^{[1
]}

Sun, Yuhui ^{[2
,3
]}

Ma, Quan-Hong ^{[2
,3
]}

Liu, Yaobo ^{[2
,3
]}

机构：

[1] Soochow Univ, Med Coll, Suzhou 215004, Jiangsu, Peoples R China

[2] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Jiangsu, Peoples R China

[3] Soochow Univ, Inst Neurosci, 199 Ren Ai Rd, Suzhou 215123, Jiangsu, Peoples R China

来源：

CELL STRESS | 2018年 / 2卷 / 07期

关键词：

Alzheimer's disease (AD); amyloid beta (A beta); synapses; neural circuits; treatment;

D O I：

10.15698/cst2018.07.143

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alzheimer's disease is one of the most severe neurodegenerative diseases among elderly people. Different pathogenic factors for Alzheimer's disease have been posited and studied in recent decades, but no effective treatment has been found, necessitating further studies. In this Viewpoint article, we assess studies on the mechanisms underlying the accumulation of amyloid beta (A beta) peptide and the formation of A beta oligomers because their accumulation in amyloid plaques in brain tissue has become a well-studied hallmark of Alzheimer's disease. We focus on the production of A beta and its impact on the function of synapses and neural circuits, and also discuss the clinical prospects for amyloid-targeted therapies.

引用

页码：150 / 161

页数：12

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