ANTI-INFLAMMATORY ACTIVITY OF EARTHWORM EXTRACTS

被引：5
|
作者：
Mathur, Abhishek [1 ]
Verma, Satish K. [1 ]
Singh, Santosh K. [2 ]
Prakash, Archana [3 ]
Prasad, G. B. K. S. [4 ]
Dua, V. K. [5 ]
机构：
[1] Sai Inst Paramed & Allied Sci, Dehra Dun, Uttarakhand, India
[2] Gayatri Inst Biomed Sci, Dehra Dun, Uttarakhand, India
[3] HIHT Univ, Dehra Dun, Uttarakhand, India
[4] Jiwaji Univ, Gwalior, Madhya Pradesh, India
[5] Natl Inst Malaria Res, Hardwar, Uttarakhand, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2011年 / 2卷 / 02期
关键词：
Eudrilus eugeniae; Anti-inflammatory activity; 95% Ethanol; Petroleum ether; 0.2 M Phosphate buffer (pH; 7.0);
D O I：
10.13040/IJPSR.0975-8232.2(2).278-81
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Earthworm plays a major role in the proper functioning of the soil ecosystem. It acts as scavenger and helps in recycling of dead and decayed plant material by feeding on them. Earthworm increases the soil fertility and is often referred to as a farmer's friend. Earthworms have been used in medicine for various remedies. In the present investigation, various solvent extracts of an earthworm, Eudrilus eugeniae were prepared and anti-inflammatory activity of these extracts were determined. The petroleum ether fraction possessed maximum anti-inflammatory activity in carrageenan induced albino rats in comparison to 95% ethanol and 0.2 M phosphate buffer (pH, 7.0) extracts. The paw volume was determined and was compared with that of aspirin, a standard anti-inflammatory drug. The results indicates that petroleum ether fraction of earthworm extract possessed similar anti-inflammatory activity as that of aspirin.
引用
收藏
页码：278 / 281
页数：4
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