SUPPRESSION OF AUDIOGENIC EPILEPTIC SEIZURES BY INTRACEREBRAL INJECTION OF A CCK GENE VECTOR

被引：2
|
作者：
ZHANG, LX
WU, M
HAN, JS
机构：
[1] BEIJING MED UNIV,NEUROSCI RES CTR,BEIJING 100083,PEOPLES R CHINA
[2] CHINESE ACAD MED SCI,NATL LAB MOLEC ONCOL,BEIJING 100021,PEOPLES R CHINA
来源：
NEUROREPORT | 1992年 / 3卷 / 08期
关键词：
GENE THERAPY; GENE TRANSFER; EPILEPTIC SEIZURE; CCK; LIPOFECTIN; RAT;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
P77PMC rat is a breed of rat with congenital audiogenic seizure (AS). AS attacks could be suppressed by cholecystokinin octapeptide (CCK-8) injected intracerebroventricularly (i.c.v.). In the present study we made i.c.v. injection of plasmid pSV2-beta-Gal or pSV2-CCK encapsulated with lipofectin. Expression of pSV2-beta-Gal in brain occurred from d 1 to d 14, with maximal expression at d 3 and d 4. After i.c.v. injection of pSV2-CCK plasmid, the AS of the P77PMC rats was markedly reduced, which was most obvious at d 3 and d 4. The time course of the AS repression was almost identical with that of pSV2-beta-Gal expression. The results suggest that the repression of the AS in P77PMC rats is accounted for by the expression of foreign CCK gene in brain tissue.
引用
收藏
页码：700 / 702
页数：3
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