SHORT-TERM THERAPY OF ATHEROSCLEROSIS WITH LOW-DOSE INDOMETHACIN - AN EXPERIMENTAL-STUDY

被引：0
|
作者：
DHAWAN, V [1 ]
GANGULY, NK [1 ]
MAJUMDAR, S [1 ]
CHAKRAVARTI, RN [1 ]
机构：
[1] POSTGRAD INST MED EDUC & RES, CHANDIGARH 160012, INDIA
来源：
JOURNAL OF MEDICAL PRIMATOLOGY | 1990年 / 19卷 / 07期
关键词：
THROMBOXANE; PROSTACYCLIN; RHESUS MONKEY; MACACA-MULATTA;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The effects of low dose indomethacin therapy in primary prevention of diet-induced atherosclerosis of rhesus monkeys was studied. The parameters studied were serum cholesterol concentration, thromboxane A2 (T x B2), prostacyclin (6-keto-PGF1-alpha) in serum/plasma, and the extent and intensity of coronary atherosclerosis. Although indomethacin did not affect serum cholesterol, it reduced serum T x B2 significantly (P < 0.01). Plasma 6-keto-PGF1-alpha was not restored to the pretreatment level. A significant protective role of the drug was noted as far as coronary atherosclerosis is concerned (P < 0.01).
引用
收藏
页码：663 / 673
页数：11
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