SHORT-TERM THERAPY OF ATHEROSCLEROSIS WITH LOW-DOSE INDOMETHACIN - AN EXPERIMENTAL-STUDY

被引：0

作者：

DHAWAN, V ^{[1
]}

GANGULY, NK ^{[1
]}

MAJUMDAR, S ^{[1
]}

CHAKRAVARTI, RN ^{[1
]}

机构：

[1] POSTGRAD INST MED EDUC & RES, CHANDIGARH 160012, INDIA

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1990年 / 19卷 / 07期

关键词：

THROMBOXANE; PROSTACYCLIN; RHESUS MONKEY; MACACA-MULATTA;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The effects of low dose indomethacin therapy in primary prevention of diet-induced atherosclerosis of rhesus monkeys was studied. The parameters studied were serum cholesterol concentration, thromboxane A2 (T x B2), prostacyclin (6-keto-PGF1-alpha) in serum/plasma, and the extent and intensity of coronary atherosclerosis. Although indomethacin did not affect serum cholesterol, it reduced serum T x B2 significantly (P < 0.01). Plasma 6-keto-PGF1-alpha was not restored to the pretreatment level. A significant protective role of the drug was noted as far as coronary atherosclerosis is concerned (P < 0.01).

引用

页码：663 / 673

页数：11

共 50 条

[1] TARDIVE-DYSKINESIA WITH LOW-DOSE, SHORT-TERM NEUROLEPTIC THERAPY
STIMMEL, GL
[J]. AMERICAN JOURNAL OF HOSPITAL PHARMACY, 1976, 33 (09): : 961 - 963
[2] SHORT-TERM LOW-DOSE TRIPLE THERAPY FOR THE ERADICATION OF HELICOBACTER-PYLORI
BAZZOLI, F
ZAGARI, RM
FOSSI, S
POZZATO, P
ALAMPI, G
SIMONI, P
SOTTILI, S
RODA, A
RODA, E
[J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1994, 6 (09) : 773 - 777
[3] Tardive dystonias induced by very short-term therapy with low-dose neuroleptics
Lohmann, T
Ebel, H
Ferbert, A
Sass, H
[J]. NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH, 1995, 3 (03) : 189 - 192
[4] TREATMENT OF CYCLICAL MASTALGIA WITH LOW-DOSE SHORT-TERM DANAZOL
SUTTON, GLJ
OMALLEY, VP
[J]. BRITISH JOURNAL OF CLINICAL PRACTICE, 1986, 40 (02): : 68 - 70
[5] Low-dose, short-term ketoprofen `safe' and `well tolerated'
[J]. Reactions Weekly, 1997, 635 (1) : 4 - 4
[6] ADOLESCENTS AND SHORT-TERM, LOW-DOSE METHADONE-MAINTENANCE
DEANGELIS, GG
LEHMANN, WX
[J]. INTERNATIONAL JOURNAL OF THE ADDICTIONS, 1973, 8 (05): : 853 - 863
[7] HRT: FDA recommends short-term, low-dose use
[J]. Reactions Weekly, 2003, 943 (1) : 3 - 3
[8] THE SHORT-TERM EFFECT OF LOW-DOSE RADIATION ON INTRACRANIAL GERMINOMA - A PATHOLOGICAL-STUDY
AYDIN, F
GHATAK, NR
RADIEKEANE, K
KINARD, J
LAND, SD
[J]. CANCER, 1992, 69 (09) : 2322 - 2326
[9] EFFICACY AND TOLERABILITY OF A SHORT-TERM, LOW-DOSE TRIPLE THERAPY FOR ERADICATION OF HELICOBACTER-PYLORI
BAZZOLI, F
ZAGARI, RM
FOSSI, S
POZZATO, P
RODA, A
RODA, E
[J]. GASTROENTEROLOGY, 1993, 104 (04) : A40 - A40
[10] Short-term hazards of low-dose radioiodine ablation therapy in postsurgical thyroid cancer patients
Lin, WY
Shen, YY
Wang, SJ
[J]. CLINICAL NUCLEAR MEDICINE, 1996, 21 (10) : 780 - 782

← 1 2 3 4 5 →