ACUTE SUBJECTIVE RESPONSES TO PAROXETINE IN NORMAL VOLUNTEERS

被引：11
|
作者：
BRAUER, LH
RUKSTALIS, MR
DEWIT, H
机构：
[1] Department of Psychiatry, University of Chicago, Chicago, IL 60637, MC3077
来源：
DRUG AND ALCOHOL DEPENDENCE | 1995年 / 39卷 / 03期
关键词：
PAROXETINE; D-AMPHETAMINE; SUBJECTIVE EFFECTS; SEROTONIN; HEALTHY VOLUNTEERS;
D O I：
10.1016/0376-8716(95)01173-2
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
The purpose of this study was to compare the subjective effects of the selective serotonin reuptake inhibitor, paroxetine, to those of the prototypic stimulant, d-amphetamine. Ten healthy volunteers attended 5 sessions and received paroxetine (10, 20, 50 mg), d-amphetamine (20 mg), and placebo. Subjective effects were measured at regular intervals for 26-30 h. Paroxetine and d-amphetamine produced highly dissimilar effects on mood. For example, whereas d-amphetamine increased ratings of euphoria, drug high, and desire for drug, paroxetine produced no effects on these measures. Conversely, whereas paroxetine increased ratings of Confusion and Fatigue, d-amphetamine did not. These findings suggest that serotonin does not play a significant role in mediating the positive subjective effects of stimulant drugs.
引用
收藏
页码：223 / 230
页数：8
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