TETRAHYDROLIPSTATIN - THERMAL AND HYDROLYTIC DEGRADATION

被引：24

作者：

STALDER, H ^{[1
]}

SCHNEIDER, PR ^{[1
]}

OESTERHELT, G ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,CENT RES UNIT,CH-4002 BASEL,SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1990年 / 73卷 / 04期

关键词：

D O I：

10.1002/hlca.19900730427

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The thermal and hydrolytic degradation of tetrahydrolipstatin (THL, 1) was investigated. All main degradation products were isolated, characterized, and synthesized. Labile intermediates unavailable to isolation were detected and identified by GC/MS analysis of their silylated derivatives, and whenever possible, compared with independently prepared reference compounds. The identified degradation products represent at least 97% of the total degradation mixture. Two main reaction pathways arc proposed. Pharmacological data are reported for the degradation mixture and the main degradation products. Copyright © 1990 Verlag GmbH & Co. KGaA, Weinheim

引用

页码：1022 / 1036

页数：15

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