CHLOROQUINE RESISTANCE OF PLASMODIUM-FALCIPARUM - A BIOLOGICAL ADVANTAGE

被引：19

作者：

WERNSDORFER, WH

LANDGRAF, B

WIEDERMANN, G

KOLLARITSCH, H

机构：

[1] UNIV VIENNA,INST SPECIF PROPHYLAXIS & TROP MED,A-1095 VIENNA,AUSTRIA

[2] UNIV SAINS MALAYSIA,NATL CTR DRUG RES,GEORGE TOWN,MALAYSIA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1995年 / 89卷 / 01期

关键词：

MALARIA; PLASMODIUM FALCIPARUM; CHLOROQUINE RESISTANCE;

D O I：

10.1016/0035-9203(95)90672-X

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The response in vitro of Plasmodium falciparum to chloroquine, mefloquine and quinine was studied in a hyperendemic peri-urban area of Accra, Ghana, during the fourth quarter of 1991, yielding a total of 159 valid tests. Schizont maturation in drug-free controls and effective chloroquine concentrations were strongly correlated. This was not seen with mefloquine or quinine. Higher mean parasitaemia in untreated oligosymptomatic carriers of overtly chloroquine-resistant P. falciparum than in carriers of more sensitive parasites was another indication of higher viability and biological advantage of chloroquine-resistant P. falciparum that may conceivably have clinical implications.

引用

页码：90 / 91

页数：2

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