MUTAGENIC AND TOXIC ACTIVITY OF SOME JORDANIAN MEDICINAL-PLANTS

被引：6
|
作者：
ALKOFAHI, A
ALKHALIL, S
机构：
[1] JORDAN UNIV SCI & TECHNOL, FAC PHARM, DEPT MED CHEM & PHARMACOGNOSY, IRBID, JORDAN
[2] UNIV JORDAN, FAC PHARM, DEPT NAT PROD, AMMAN, JORDAN
来源：
INTERNATIONAL JOURNAL OF PHARMACOGNOSY | 1995年 / 33卷 / 01期
关键词：
PLANT EXTRACTS; BRINE SHRIMP; CYTOTOXICITY; MUTAGENICITY;
D O I：
10.3109/13880209509088149
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A total of 39 ethanol extracts of Jordanian plants were examined for cytotoxicity and mutagenicity. Among the tested plants, 8 extracts were active in the brine shrimp cytotoxicity bioassay with LC(50) values in the range of 2.5-870 mu g/ml. These positive extracts were further rested for their antirumor activity on human tumor cell lines in culture. Eminium spiculatum showed activity against a lung carcinoma line (A-549) with art ED(50) of 0.0793 mu g/ml. Regarding mutagenic effect, 16 of the extracts were active on Salmonella typhim-urium strains TA98 or TA102, and the extract of Podonosma oriantalis showed mutagenic activity in both strains.
引用
收藏
页码：61 / 64
页数：4
相关论文
共 50 条
  • [11] CONSTITUENTS OF SOME ASIAN MEDICINAL-PLANTS
    TAYLOR, WC
    [J]. PURE AND APPLIED CHEMISTRY, 1994, 66 (10-11) : 2375 - 2378
  • [12] HERBICIDE RESIDUES IN SOME MEDICINAL-PLANTS
    MAAS, G
    [J]. PLANTA MEDICA, 1979, 36 (03) : 251 - 251
  • [13] STUDY OF SOME MALAGASY MEDICINAL-PLANTS
    POISSON, J
    PESSONNIER, A
    BONNET, D
    BOUDET, G
    BERNARD, F
    CAHEN, R
    SAUTAI, M
    LAMBERT, N
    DUVAL, N
    NADAUD, J
    [J]. ANNALES PHARMACEUTIQUES FRANCAISES, 1972, 30 (04): : 241 - +
  • [14] ANTIFUNGAL SPECTRUM OF SOME MEDICINAL-PLANTS
    CHARYA, MAS
    REDDY, SM
    [J]. NATIONAL ACADEMY SCIENCE LETTERS-INDIA, 1981, 4 (08): : 313 - 315
  • [15] ANTIVIRAL ACTIVITY OF AFRICAN MEDICINAL-PLANTS
    BEUSCHER, N
    BODINET, C
    NEUMANNHAEFELIN, D
    MARSTON, A
    HOSTETTMANN, K
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 1994, 42 (02) : 101 - 109
  • [16] ANTIINFLAMMATORY ACTIVITY OF SOME MEDICINAL-PLANTS OF THE UNITED-ARAB-EMIRATES
    WASFI, IA
    BASHIR, AK
    ABDALLA, AA
    BANNA, NR
    TANIRA, MOM
    [J]. INTERNATIONAL JOURNAL OF PHARMACOGNOSY, 1995, 33 (02): : 124 - 128
  • [17] Antibacterial activity of Jordanian medicinal plants
    Nimri, LF
    Meqdam, MM
    Alkofahi, A
    [J]. PHARMACEUTICAL BIOLOGY, 1999, 37 (03) : 196 - 201
  • [18] Anti-Helicobactor pylori activity of some Jordanian medicinal plants
    Masadeh, Majed M.
    Alkofahi, Ahmad S.
    Alzoubi, Karem H.
    Tumah, Haitham N.
    Bani-Hani, Kamal
    [J]. PHARMACEUTICAL BIOLOGY, 2014, 52 (05) : 566 - 569
  • [19] ORAL HYPOGLYCEMIC ACTIVITY OF SOME MEDICINAL-PLANTS OF SRI-LANKA
    KARUNANAYAKE, EH
    WELIHINDA, J
    SIRIMANNE, SR
    SINNADORAI, G
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 1984, 11 (02) : 223 - 231
  • [20] MEDICINAL-PLANTS
    FLEURENTIN, J
    PELT, JM
    [J]. RECHERCHE, 1990, 21 (222): : 810 - 818
12345