SOME FORMULATION FACTORS INFLUENCING THE RATE OF DRUG RELEASE FROM BIOADHESIVE MATRICES

被引：18
|
作者：
SMART, JD
机构：
[1] The School of Pharmacy and Biomedical Sciences, Portsmouth Polytechnic, Portsmouth
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 02期
关键词：
D O I：
10.3109/03639049209043695
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The development of monolithic matrices with controlled release and mucosa-adhesive properties was investigated. After an initial screening procedure for formulations that showed stability and minimal swelling, the rate of release of a model water soluble drug from various polyacrylic acid containing matrices was evaluated. All the formulations gave a prolonged drug release relative to a lactose containing control formulation. A formulation containing Carbopol 934P and CaCl2 was found to give the slowest rate of drug release (t50% of 7.77h), with release kinetics nearest to the ideal zero order. When tested in a modified tensiometer it was found that the inclusion of a relatively high loading of a model drug did not adversely affect the adhesive properties of these formulations.
引用
收藏
页码：223 / 232
页数：10
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