3-METHYLADENINE RESIDUES IN DNA INDUCE THE SOS FUNCTION SFIA IN ESCHERICHIA-COLI

被引：144
|
作者：
BOITEUX, S [1 ]
HUISMAN, O [1 ]
LAVAL, J [1 ]
机构：
[1] UNIV PARIS 07, CNRS, INST JACQUES MONOD, F-75221 PARIS 05, FRANCE
来源：
EMBO JOURNAL | 1984年 / 3卷 / 11期
关键词：
D O I：
10.1002/j.1460-2075.1984.tb02175.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The induction by methylating agents of the SOS function sfiA was measured by means of a sfiA::lac operon fusion in E. coli mutants defective in alkylation repair. The sfiA operon was turned on at a 10-fold lower concentration of methylmethane sulfonate or dimethyl sulfate in tagA strains, lacking specific 3-methyladenine-DNA glycosylase, than in wild-type strains. The induction of sfiA by UV light was not affected by a tagA mutation. Evidently, tagA strains specifically accumulate 3-methyladenine in their DNA. It was concluded that the persistence of 3-methyladenine in E. coli DNA most likely induces the SOS functions. Results on in vitro DNA synthesis further suggest that this induction is due to an unscheduled arrest of DNA synthesis at this lesion.
引用
收藏
页码：2569 / 2573
页数：5
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