HYPOTONIC TREATMENT LEADS TO CHROMOSOMAL-ABERRATIONS BUT NOT TO SISTER-CHROMATID EXCHANGES IN HUMAN-LYMPHOCYTES

被引：11

作者：

KALWEIT, S

NOWAK, C

OBE, G

机构：

[1] UNIV ESSEN GESAMTHSCH,FACHBEREICH 9,DEPT GENET,POB 103764,W-4300 ESSEN 1,GERMANY

[2] FREE UNIV BERLIN,INST GENET,W-1000 BERLIN 33,GERMANY

来源：

MUTATION RESEARCH | 1990年 / 245卷 / 01期

关键词：

Chromosome aberration; Human lymphocytes; Hypotonic treatment;

D O I：

10.1016/0165-7992(90)90017-E

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human peripheral lymphocytes were isolated from whole blood and exposed to culture medium of reduced osmolality. This hypotonic treatment led to a significant increase in the frequencies of chromosomal aberrations when the osmolality was reduced to 60 mOsm/kg H20 and below. Maximum damage occurred when the hypotonic treatment was done 27 or 30 h after starting the cultures. We also looked for the induction of sister-chromatid exchanges (SCE) by hypotonic culture conditions, but the SCE frequencies were not influenced. © 1990.

引用

页码：5 / 9

页数：5

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