CHARACTERIZATION OF THE GASTROPROTECTIVE EFFECTS OF N,N-DIETHYL-2-[4-(PHENYLMETHYL)PHENOXY]-ETHANAMINE HYDROCHLORIDE, A NON-H1 NON-H2 HISTAMINE ANTAGONIST

被引:15
|
作者
GLAVIN, GB
GERRARD, JM
机构
[1] UNIV MANITOBA,FAC MED,DEPT SURG,WINNIPEG R3T 2N2,MANITOBA,CANADA
[2] UNIV MANITOBA,FAC MED,DEPT PEDIAT,WINNIPEG R3T 2N2,MANITOBA,CANADA
[3] MANITOBA INST CELL BIOL,WINNIPEG,MANITOBA,CANADA
关键词
DIPHENYLMETHANE DERIVATIVE; PROSTAGLANDIN; PROSTACYCLIN; HISTAMINE; STRESS ULCER; ETHANOL ULCER; GASTRIC ACID SECRETION; INDOMETHACIN;
D O I
10.1159/000200489
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCI (DPPE) is an antihistamine with a unique profile of activity in the stomach. It is antisecretory and blocks the formation of experimental cold/stress- and ethanol-induced gastric lesions, as well as cysteamine-induced duodenal ulcers in a fashion more potent than observed with histamine H2 antagonists such as cimetidine. We now demonstrate that the antiulcer effects of DPPE are associated with a dramatic (10-fold) rise in the stable prostacyclin hydration product 6-keto-prostaglandin F1(alpha) in gastric secretion collected from conscious rats. Cyclooxygenase inhibitors such as acetylsalicylic acid, indomethacin and sodium meclofenamate abolish high-dose DPPE-induced gastroprotection, whereas sodium salicylate, a lipoxygenase inhibitor, does not. These data suggest that DPPE-induced gastroprotection is mediated, at least in part, through an increase in endogenous prostacyclin (prostaglandin I2) synthesis in the gastric mucosa. These data are not consistent with an effect of DPPE primarily at the H2 receptor, but are consistent with the recent suggestion that DPPE antagonizes histamine at H(IC), an intracellular histamine site.
引用
收藏
页码:143 / 148
页数:6
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