Steel nitriding is a thermo-chemical process largely employed in the machine components production to solve mainly wear and fatigue damage in materials. The process is strongly influenced by many different variables such as steel composition, nitrogen potential (range 0.8-35), temperature (range 350-1200 degrees C), time (range 2-180 hours). In the present study, the influence of such parameters affecting the nitriding layers' thickness, hardness, composition and residual stress was evaluated. The aim was to streamline the process by numerical-experimental analysis allowing to define the optimal conditions for the success of the process. The optimization software that was used is modeFRONTIER (Esteco), through which was defined a set of input parameters (steel composition, nitrogen potential, nitriding time, etc.) evaluated on the basis of an optimization algorithm carefully chosen for the multi-objective analysis. The mechanical and microstructural results belonging to the nitriding process, performed with different processing conditions for various steels, are presented. The data were employed to obtain the analytical equations describing nitriding behavior as a function of nitriding parameters and steel composition. The obtained model was validated through control designs and optimized by taking into account physical and processing conditions. (C) 2015, Karabuk University. Production and hosting by Elsevier B.V.