BEHAVIORAL CONSEQUENCES OF COCAINE WITHDRAWAL IN RATS

被引：26
|
作者：
FUNG, YK
RICHARD, LA
机构：
[1] University of Nebraska Medical Center, College of Dentistry, Department of Oral Biology, Lincoln, Nebraska, 68583-0740
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1994年 / 46卷 / 02期
关键词：
D O I：
10.1111/j.2042-7158.1994.tb03761.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study was designed to examine the impact of cocaine withdrawal on several behavioural parameters in rats. After 1 and 3 day withdrawal from continuous cocaine administration (50 mg kg(-1) for 28 days, subcutaneous infusion via osmotic minipumps), rats showed significant changes in spontaneous locomotor activity, conditioned avoidance response and increased levels of anxiety. However, cocaine withdrawal did not alter the motor co-ordination, body weight, food and water consumption of these animals. The neurochemical effects of cocaine on central dopaminergic neuronal systems may account for locomotor deficit observed in these cocaine-withdrawal animals.
引用
收藏
页码：150 / 152
页数：3
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