HAPTOGLOBIN POLYMORPHISM AND THE IMMUNE-RESPONSE AFTER HEPATITIS-B VACCINATION

被引：34
|
作者：
LOUAGIE, H
DELANGHE, J
DESOMBERE, I
DEBUYZERE, M
HAUSER, P
LEROUXROELS, G
机构：
[1] UNIV HOSP GENT,CENT LAB,DE PINTELAAN 185,B-9000 GHENT,BELGIUM
[2] STATE UNIV GHENT,DEPT CLIN CHEM,B-9000 GHENT,BELGIUM
[3] SMITHKLINE BEECHAM BIOL SA,B-1330 RIXENSART,BELGIUM
来源：
VACCINE | 1993年 / 11卷 / 12期
关键词：
HEPATITIS-B VACCINATION; HAPTOGLOBIN; GENETIC POLYMORPHISM;
D O I：
10.1016/0264-410X(93)90041-U
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
One hundred healthy Caucasian medical students (age 22 +/- 1 years) were vaccinated with a recombinant hepatitis B vaccine and their haptoglobin types were determined. A relationship between haptoglobin type and immune response to the vaccine was observed. Subjects with a 2-2 haptoglobin phenotype produced significantly lower heptatis B antibody titres than those having a 1-1 or 2-1 haptoglobin phenotype. The haptoglobin phenotypes not only influenced the magnitude but also the kinetics of the anti-HBs response. For all haptoglobin types, haptoglobin concentration and immune response to the vaccine behaved independently.
引用
收藏
页码：1188 / 1190
页数：3
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