P2X3 and P2X2/3 receptor antagonists

被引：1
|
作者：
Bolcskei, Hedvig [1 ]
Farkas, Bence [1 ]
机构：
[1] Gedeon Richter Plc, 10 POB 27, H-1475 Budapest, Hungary
来源：
PHARMACEUTICAL PATENT ANALYST | 2014年 / 3卷 / 01期
关键词：
D O I：
10.4155/PPA.13.70
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This review provides a concise summary of the molecular properties of the ligand-gated P2X receptors, in particular those containing the X3 subunit, as well as an overview comprising the most important patent applications on P2X3 and P2X2/3 receptor antagonists published since 2001. This review is mainly focused on small molecules with P2X3 and/or P2X2/3 antagonist properties. The most important classes of the patented compounds and conditions frequently claimed as their therapeutic targets are also discussed. Moreover, biological activity data from the cited patents and general prediction of druglikeness of the claimed compounds are also provided.
引用
收藏
页码：53 / 64
页数：12
相关论文
共 50 条
  • [31] Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model
    Ballini, E.
    Virginio, C.
    Medhurst, S. J.
    Summerfield, S. G.
    Aldegheri, L.
    Buson, A.
    Carignani, C.
    Chen, Y. H.
    Giacometti, A.
    Lago, I.
    Powell, A. J.
    Jarolimek, W.
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2011, 163 (06) : 1315 - 1325
  • [32] P2X2/3 and P2X3 receptors contribute to the metaboreceptor component of the exercise pressor reflex
    McCord, Jennifer L.
    Tsuchimochi, Hirotsugu
    Kaufman, Marc P.
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2010, 109 (05) : 1416 - 1423
  • [33] Intraganglionic laminar endings in the rat esophagus contain purinergic P2X2 and P2X3 receptor immunoreactivity
    Z.-J. Wang
    W. L. Neuhuber
    [J]. Anatomy and Embryology, 2003, 207 : 363 - 371
  • [34] Intraganglionic laminar endings in the rat esophagus contain purinergic P2X2 and P2X3 receptor immunoreactivity
    Wang, ZJ
    Neuhuber, WL
    [J]. ANATOMY AND EMBRYOLOGY, 2003, 207 (4-5): : 363 - 371
  • [35] Comparative Analysis of P2X1, P2X2, P2X3, and P2X4 Receptor Subunits in Rat Nodose Ganglion Neurons
    Wang, Lizhao
    Feng, Dan
    Yan, Huanhuan
    Wang, Zhongping
    Pei, Lei
    [J]. PLOS ONE, 2014, 9 (05):
  • [36] Distribution of P2X2 and P2X3 receptors in the geniculate and petrosal ganglia in the rat and mouse
    Ishida, Yusuke
    Ugawa, Shinya
    Ueda, Takashi
    Shimada, Shoichi
    [J]. NEUROSCIENCE RESEARCH, 2008, 61 : S249 - S249
  • [37] Upregulation of P2X2 and P2X3 receptors in rats with hyperalgesia induced by heroin withdrawal
    Leng, Changlong
    Chen, Lin
    Gong, Xiaokang
    Ma, Baomiao
    Gan, Weimin
    Si, Yuanren
    Xiao, Huaqiao
    Li, Chaoying
    [J]. NEUROREPORT, 2018, 29 (08) : 678 - 684
  • [38] Do P2X2/3 and P2X3 receptors play a role in the exercise pressor reflex in cats?
    McCord, Jennifer L.
    Tsuchimochi, Hirotsugu
    Kaufman, Marc P.
    [J]. FASEB JOURNAL, 2010, 24
  • [39] Heterogeneity of the Functional Expression of P2X3 and P2X2/3 Receptors in the Primary Nociceptive Neurons of Rat
    Yu. V. Pankratov
    U. V. Lalo
    A. N. Dashkin
    O. A. Krishtal
    [J]. Neurochemical Research, 2001, 26 : 993 - 1000
  • [40] Biochemical evidence against P2X2 and P2X3 receptor regulation by direct PKC-mediated phosphorylation
    Franklin, C.
    Schmalzing, G.
    Hausmann, R.
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2007, 375 : 27 - 27
12345