P2X3 and P2X2/3 receptor antagonists

被引：1
|
作者：
Bolcskei, Hedvig [1 ]
Farkas, Bence [1 ]
机构：
[1] Gedeon Richter Plc, 10 POB 27, H-1475 Budapest, Hungary
来源：
PHARMACEUTICAL PATENT ANALYST | 2014年 / 3卷 / 01期
关键词：
D O I：
10.4155/PPA.13.70
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This review provides a concise summary of the molecular properties of the ligand-gated P2X receptors, in particular those containing the X3 subunit, as well as an overview comprising the most important patent applications on P2X3 and P2X2/3 receptor antagonists published since 2001. This review is mainly focused on small molecules with P2X3 and/or P2X2/3 antagonist properties. The most important classes of the patented compounds and conditions frequently claimed as their therapeutic targets are also discussed. Moreover, biological activity data from the cited patents and general prediction of druglikeness of the claimed compounds are also provided.
引用
收藏
页码：53 / 64
页数：12
相关论文
共 50 条
  • [1] Discovery and optimization of P2X3 and dual P2X3/P2X2/3 antagonists with therapeutic potential
    Dillon, Michael
    [J]. PURINERGIC SIGNALLING, 2008, 4 : S16 - S16
  • [2] Regulation of the P2X2/P2X3 receptor by substance P
    Paukert, M
    Osterroth, R
    Brändle, U
    Glowatzki, E
    Gründer, S
    Ruppersberg, JP
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 : 457 - 457
  • [3] Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications
    Marucci, Gabriella
    Dal Ben, Diego
    Buccioni, Michela
    Navia, Aleix Marti
    Spinaci, Andrea
    Volpini, Rosaria
    Lambertucci, Catia
    [J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2019, 29 (12) : 943 - 963
  • [4] Development of novel P2X3 / P2X2/3 receptor antagonists for the treatment of pain and urinary dysfunction
    Davenport, Adam J.
    Stimson, Christopher
    Savidge, Jonathan
    Albrecht, Claudia
    Ebneth, Andreas
    Cesura, Andrea
    Hallett, David
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [5] Cystometric studies and action of capsaicin in conscious P2X3, P2X2 and P2X2/P2X3 knockout mice
    Zhu, QM
    Hu, DQ
    Blue, DR
    Cockayne, DA
    Ford, AP
    [J]. JOURNAL OF UROLOGY, 2002, 167 (04): : 35 - 36
  • [6] P2X2 and P2X3 receptor expression in the gallbladder of the guinea pig
    Ruan, HZ
    Burnstock, G
    [J]. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2004, 111 (02): : 89 - 96
  • [7] Identification of novel, orally active antagonists of P2X3 and P2X2/3 purinergic receptors
    Hsu, David
    Wei, Zhi-Liang
    O'Mahoney, Donogh
    Bian, Di
    Chi, Candace
    Defalco, Jeff
    Dourado, Michelle
    Dodson, G. Steven
    Kincaid, John
    Kelly, Michael
    [J]. PURINERGIC SIGNALLING, 2008, 4 : S124 - S124
  • [8] Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies
    Shcherbatko, Anatoly
    Foletti, Davide
    Poulsen, Kris
    Strop, Pavel
    Zhu, Guoyun
    Hasa-Moreno, Adela
    Witt, Jody Melton
    Loo, Carole
    Krimm, Stellanie
    Pios, Ariel
    Yu, Jessica
    Brown, Colleen
    Lee, John K.
    Stroud, Robert
    Rajpal, Arvind
    Shelton, David
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (23) : 12254 - 12270
  • [9] Kinetic and Pharmacological Properties of P2X3 and P2X2/3 Receptors
    Costantin, James L.
    Strassmaier, Timothy
    Rotordam, Giustina M.
    Goetze, Tom
    Becker, Nadine
    Obergrussberger, Alison
    Bruggemann, Andrea
    George, Michael
    Fertig, Niels
    [J]. BIOPHYSICAL JOURNAL, 2020, 118 (03) : 118A - 119A
  • [10] Antinociceptive properties of a non-nucleotide P2X3/P2X2/3 receptor antagonist
    McGaraughty, S
    Jarvis, MF
    [J]. DRUG NEWS & PERSPECTIVES, 2005, 18 (08) : 501 - 507
12345