BORON NEUTRON-CAPTURE THERAPY OF CANCERS - NUCLEIC BASES, NUCLEOSIDES, AND OLIGONUCLEOTIDES AS POTENTIAL BORON CARRIERS

被引：0

作者：

LESNIKOWSKI, ZJ ^{[1
]}

SCHINAZI, RF ^{[1
]}

机构：

[1] EMORY UNIV,SCH MED,DEPT PEDIAT,BIOCHEM PHARMACOL LAB,ATLANTA,GA 30322

来源：

POLISH JOURNAL OF CHEMISTRY | 1995年 / 69卷 / 06期

关键词：

NUCLEOSIDES; OLIGONUCLEOTIDES; BORON NEUTRON CAPTURE THERAPY; CANCER THERAPY;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Basic principle and practice of boron neutron capture therapy of cancers (BNCT) is described. Boron modified oligonucleotides and their components, nucleosides and nucleic bases, and in particular derivatives containing boron cluster ligands are discussed. Boron bearing oligonucleotides are potentially tumor specific, boron rich carrier molecules for BNCT. They may find application as antisense agents for antisense oligonucleotide thera py (AOT) of cancers a nd viral infections, and as molecular probes for diagnosis of genetic diseases.

引用

页码：827 / 840

页数：14

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