ACUTE TOXICITY STUDY OF ETHANOLIC EXTRACT OF SOLANUM LYCOPERSICUM (LEAF) IN SWISS ALBINO MICE

The Present Study was planned to assess the acute toxicity of Solanum lycopersicum Leaf. The study was designed according to the OECD guidelines as per that the dose level used as 5, 50, 300, 2000, 4000 mg/kg. Mice were orally administrated single dose of 200 and 400 mg/kg of ethanolic extract of Solanum lycopersicum. Physical, Biochemical, Hematological as well as histopathological parameters were unaltered throughout the study. Mortality, signs of toxicity, bodyweight, food consumption and gross findings were observed for 14 days post treatment of Solanum lycopersicum extract. In addition, no significant differences were noticed in the body and organ weights between the control and treated groups. These results state that aqueous extract of Solanum lycopersicum is toxicologically safe by oral administration.