STUDY OF THE IGA SUBCLASSES IN SYMPTOMATIC PATIENTS WITH IGA DEFICIENCY

BACKGROUND: Patients with IgA deficiency may be asymptomatic or may present recurrent infections mainly respiratory. A possible explanation for this variety of symptoms may be the association with a deficiency of IgG subclasses. METHODS: Twenty-five patients with a symptomatic IgA deficiency with a mean age of 18 +/- 12 years were studied. The quantification of the IgG subclasses was performed by ELISA test with antisubclass specific monoclonal murine antibodies. Serum from 100 healthy adults was collected to determine normal values of the IgG subclasses. RESULTS: Twenty-five (48%) had a deficiency of associated IgG subclasses (6 IgG2 deficiency, 1 lgG3, 3 IgG4 and 2 combined deficiency). The patient with a deficiency of associated IgG subclasse had more recurrent respiratory infections (chi(2), P<0.03) and pneumonias (chi(2), p<0.04). This group also had a greater FEV1 alteration (Student-t test, p<0.04). CONCLUSlONS: Patients with symptomatic IgA deficiency frequently present IgG subclass deficiency and are more likely to have recurrent respiratory infections and greater changes in pulmonary function.