FORMATION AND REMOVAL OF DNA ADDUCTS IN LIVER OF RATS TREATED WITH HEPATOCARCINOGENS 2-AMINOFLUORENE OR 2-ACETYLAMINOFLUORENE

被引：0
|
作者：
WIDLAK, P
RZESZOWSKAWOLNY, J
机构：
来源：
ACTA BIOCHIMICA POLONICA | 1991年 / 38卷 / 01期
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The level of adducts in DNA of rats treated with 2-aminofluorene (2-AF) and 2-acetylaminofluorene (2-AAF) was compared at the times from 1 h till 28 days after injection. The highest amount of DNA adducts was observed 12 h after treatment with 2-AF and 24 h after treatment with 2-AAF, and reached values of about 18 and 21 fmol per mu-g DNA, respectively. Participation of the nonacetylated form, dG-C8-AF, in the total amount of DNA adducts was only slightly greater in rats treated with 2-AF then in those treated with 2-AAF.
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页码：145 / 150
页数：6
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