AVERSIVE TASTE STIMULI INCREASE CGRP LEVELS IN THE GUSTATORY INSULAR CORTEX OF THE RAT

被引：13

作者：

YAMAMOTO, T ^{[1
]}

MATSUO, R ^{[1
]}

ICHIKAWA, H ^{[1
]}

WAKISAKA, S ^{[1
]}

AKAI, M ^{[1
]}

IMAI, Y ^{[1
]}

YONEHARA, N ^{[1
]}

INOKI, R ^{[1
]}

机构：

[1] OSAKA UNIV, FAC DENT, DEPT ORAL ANAT & PHARMACOL, SUITA, OSAKA 565, JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期

关键词：

Calcitonin gene-related peptide; Immunohistochemistry; Insular cortex; Radioimmunoassay; Taste;

D O I：

10.1016/0304-3940(90)90197-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Calcitonin gene-related peptide-like immunoreactivity (CGRP-IR) was surveyed immunohistochemically in the insular cortex of the rat, and the levels of insular cortical CGRP-IR were measured with the radioimmunoassay method following intraoral stimulation with various taste stimuli. CGRP-IR was localized in nerve fibers within the agranular and dysgranular insular cortices. The CGRP-IR levels in the rostral (gustatory) part of the insular cortex were increased significantly by strongly aversive taste stimuli such as quinine hydrochloride and conditioned taste stimuli (NaCl and sucrose) which animals had been taught to avoid. The results suggest that CGRP in the gustatory insular cortex is concerned with rejection or avoidance behaviors to aversive taste stimuli. © 1990.

引用

页码：167 / 172

页数：6

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