TYROSINE-130 IN BULLFROG THYROGLOBULIN IS A THYROID-HORMONE GENERATING SITE

被引：5
|
作者：
HAYASHI, H
OHMIYA, Y
SUZUKI, S
机构：
[1] Institute of Endocrinology, Gunma University, Maebashi
来源：
FEBS LETTERS | 1991年 / 292卷 / 1-2期
关键词：
BULLFROG THYROGLOBULIN; PARTIAL AMINO ACID SEQUENCE; THYROID HORMONE GENERATING SITE;
D O I：
10.1016/0014-5793(91)80860-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bullfrog thyroglobulin was digested with lysyl endopeptidase, known to be highly specific to cut the C-terminal side of lysine residue in protein, after reduction and carboxymethylation. We isolated one peptide which lacked the C-terminal lysine, and which corresponds to 103-129 of bovine thyroglobulin sequence. Tyrosine 130 in the mammalian thyroglobulin molecule is known to be an iodination site. These findings suggest that tyrosine 130 in frog thyroglobulin is a thyroid hormone generating site.
引用
收藏
页码：168 / 170
页数：3
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