The Childhood Asthma Management Program (CAMP): contributions to the understanding of therapy and the natural history of childhood asthma
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作者:
Covar, Ronina A.
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机构:
Natl Jewish Hlth, 1400 Jackson St, Denver, CO 80206 USANatl Jewish Hlth, 1400 Jackson St, Denver, CO 80206 USA
Covar, Ronina A.
[1
]
Fuhlbrigge, Anne L.
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机构:
Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Pulm & Crit Care Div, Boston, MA USANatl Jewish Hlth, 1400 Jackson St, Denver, CO 80206 USA
Fuhlbrigge, Anne L.
[2
]
Williams, Paul
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机构:
Univ Washington, Sch Med, ASTHMA, Inc Clin Res Ctr, Seattle, WA 98115 USANatl Jewish Hlth, 1400 Jackson St, Denver, CO 80206 USA
Williams, Paul
[3
]
Kelly, H. William
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机构:
Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87114 USANatl Jewish Hlth, 1400 Jackson St, Denver, CO 80206 USA
Kelly, H. William
[4
]
机构:
[1] Natl Jewish Hlth, 1400 Jackson St, Denver, CO 80206 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Pulm & Crit Care Div, Boston, MA USA
[3] Univ Washington, Sch Med, ASTHMA, Inc Clin Res Ctr, Seattle, WA 98115 USA
[4] Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87114 USA
Asthma;
Childhood;
Spirometry;
Airway hyperresponsiveness;
Inhaled corticosteroids;
Bronchodilators;
Bronchodilator response;
Allergy;
Pharmacogenomics;
Bone mineral density;
Vitamin D;
Linear growth;
Cataracts;
Hypothalamic-pituitary-adrenal axis;
Remission;
Progression;
Exacerbation;
Oral corticosteroids;
Nedocromil;
Forced expiratory volume in one second (FEV1);
Forced vital capacity (FVC);
Symptoms;
Health care utilization;
Phenotype;
Genetic polymorphism;
Eosinophils;
D O I:
10.1007/s13665-012-0026-9
中图分类号:
R56 [呼吸系及胸部疾病];
学科分类号:
摘要:
The Childhood Asthma Management Program (CAMP) has been in continuous existence for almost two decades, which makes it the largest randomized, placebocontrolled clinical trial with extended follow-up for children with mild to moderate asthma. As such, its cumulative data from baseline, active treatment, and posttreatment have proved to be an invaluable resource for not only assessing the efficacy and safety of long-term inhaled corticosteroid therapy in childhood, but for discovery of many other aspects of childhood asthma, including genetics and biomarkers.