DEPRESSION OF CALCIUM-PUMP ACTIVITY IN RENAL-CORTEX OF VITAMIN-D-DEFICIENT RATS WITH SECONDARY HYPERPARATHYROIDISM

被引：1
|
作者：
TSUKAMOTO, Y
TAMURA, T
SAITOH, M
TAKITA, Y
NAKANO, T
机构：
[1] KITASATO UNIV, SCH MED, DEPT MED, 1-15-1 KITASATO, SAGAMIHARA, KANAGAWA 228, JAPAN
[2] CHUGAI PHARMACEUT CO LTD, CTR MED SCI, APPL RES LABS, TOKYO 171, JAPAN
[3] TOKYO MED & DENT UNIV, DEPT INTERNAL MED 2, TOKYO 113, JAPAN
来源：
ACTA ENDOCRINOLOGICA | 1990年 / 123卷 / 04期
关键词：
D O I：
10.1530/acta.0.1230438
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To examine the hormonal regulation of the ATP-dependent Ca2+ pump in the kidneys, the ATP-dependent Ca2+ uptake by the basolateral membrane vesicles in the renal cortex was measured using radioactive calcium (45Ca2+) in rats with vitamin D deficiency or rats undergoing thyroparathyroidectomy. The V(max) of the Ca2+ pump activity was increased not only by administering calcitriol, but also by normalizing the serum calcium level in vitamin D-deficient rats. PTH suppressed the Ca2+ pump activity in normocalcemic vitamin D-deficient rats. Thyroparathyroidectomy did not affect the Ca2+ pump activity in the kidneys of normal rats. It was concluded that the ATP-dependent Ca2+ pump activity was depressed by secondary hyperparathyroidism in vitamin D-deficient rats.
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页码：438 / 444
页数：7
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