The association between allergic rhinitis with migraine: A systematic review and meta-analysis study

Background: Allergic rhinitis (AR) and migraine are two diseases with high rates in the population that can effect on quality of life. We aimed to assess the migraine frequency in patients with AR compared with controls in a meta-analysis study. Materials and Methods: Four databases including PubMed, Web of Science, Scopus, and Cochrane Library were searched up to January 2018. A random-effects meta-analysis was used by Review Manager 5.3 using odds ratio (OR) and 95% confidence intervals. Results: Out of 310 studies found in data based, 5 studies were included and analyzed in meta-analysis study. The pooled OR repotting the prevalence of migraine in patients was compared with controls was 3.83 (65% CI: 2.40, 6.11; P<0.00001). The pooled OR reporting the prevalence of migraine with aura and without aura in patients compared with controls was 4.35 (65% CI: 3.34, 5.69; P<0.00001), and 3.54 (65% CI: 2.110, 5.94; P<0.00001), respectively. Conclusion: AR patients were at higher risk to develop the migraine compared with nAR subjects, suggesting that physicians need to pay more attention when complaints of the headache in the patients.