THE BIOLOGY OF THE EOSINOPHILIC LEUKOCYTE

被引：212
|
作者：
GLEICH, GJ
ADOLPHSON, CR
LEIFERMAN, KM
机构：
[1] MAYO CLIN & MAYO FDN, DEPT INTERNAL MED, ROCHESTER, MN 55905 USA
[2] MAYO CLIN & MAYO FDN, DEPT IMMUNOL, ROCHESTER, MN 55905 USA
来源：
ANNUAL REVIEW OF MEDICINE | 1993年 / 44卷
关键词：
ASTHMA; INTERLEUKIN-5; EOSINOPHIL GRANULE MAJOR BASIC PROTEIN;
D O I：
10.1146/annurev.me.44.020193.000505
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The eosinophil is characterized by specific cytoplasmic granules that contain a series of cationic toxins able to kill many targets, including helminths. protozoa, bacteria, and other cells. In bronchial asthma, considerable evidence exists that the eosinophil releases granule proteins, especially the major basic protein (MBP), which in turn mediate tissue abnormalities. Among eosinophil-activating factors, IL-5 has been associated with helminth infection and hypersensitivity diseases and would appear to be an attractive target for pharmacological intervention.
引用
收藏
页码：85 / 101
页数：17
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