Divergent defluorocarboxylation of α-CF3 alkenes with formate via photocatalyzed selective mono-or triple C–F bond cleavage

被引：0

作者：

Xing-Yu Wang ^{[1
]}

Pei Xu ^{[1
]}

Wen-Wen Liu ^{[1
]}

Hao-Qiang Jiang ^{[1
]}

Song-Lei Zhu ^{[1
]}

Dong Guo ^{[1
]}

Xu Zhu ^{[1
]}

机构：

[1] Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University

来源：

Science China(Chemistry) | 2024年 / 67卷 / 01期

基金：

中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

O643.36 [催化剂]; O644.1 [光化学];

学科分类号：

070304 ; 081704 ; 081705 ;

摘要：

Unprecedented divergent synthesis of gem-difluorovinylacetic acid and glutaric acid derivatives from α-CF3alkenes with formate as the carbonyl source was disclosed.The reaction can undergo selective mono-or triple C-F bond cleavage by simply switching the photocatalyst and hydrogen atom transfer(HAT) catalyst under visible-light-induced conditions at room temperature.Foramte acts as both the C1 source and the reductant through the generation of CO2·-species,which underwent Giese radical addition to electron-deficient alkenes to trigger the consecutive C-F bond cleavage and carboxylation process.

引用

页码：368 / 373

页数：6

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