The review presents the current classification of antimicrobial peptides (AMP), which are the main component of innate immunity. The mechanism of their action and the molecular basis of the formation of resistance towards these peptides are described. Data on the use of AMP for the treatment of various infectious diseases, as well as the state of the art in genetic therapy using AMP, are given.
机构:
Univ Catolica Dom Bosco, Biotecnol, S Inova Biotech, Campo Grande, MS, BrazilUniv Catolica Dom Bosco, Biotecnol, S Inova Biotech, Campo Grande, MS, Brazil
dos Santos, Cristiane
Franco, Octavio Luiz
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Univ Catolica Dom Bosco, Biotecnol, S Inova Biotech, Campo Grande, MS, Brazil
Univ Catolica Brasilia, Ciencias Genom & Biotecnol, Ctr Anal Proteom & Bioquim, Brasilia, DF, BrazilUniv Catolica Dom Bosco, Biotecnol, S Inova Biotech, Campo Grande, MS, Brazil