Design of Real-Time Temperature Monitoring and Control System for Multimodal Ablation

By combining cryogenic cryotherapy and high-temperature radiofrequency therapy, multimodal ablation generates a rapidly changing temperature field in tissue by heating after pre-freezing. This method completely breaks tumour cells and releases a large amount of active antigen. Compared with the traditional single modality, the thermal physical ablation method has been shown to have a greater therapeutic effect, but it presents challenges in terms of precise monitoring and rapid control of the temperature during the treatment process. To solve this problem, we propose a temperature control system design utilizing aspects of probe sensing, real-time software and hardware signal interfaces, and dynamic compensation control strategies to accurately monitor the temperature changes during multimodal ablation treatment. The results show that the design system has millisecond-level high-speed control capability, an accuracy of 0.5 °C, and the dynamic response time is less than 0.1 s. Furthermore, the temperature fluctuation in in vivo experiments is less than 0.5 °C. © 2022, Shanghai Jiao Tong University.